Collagen - iimolekyuli ezinkulu nezincinci

I-Collagen inokwahlulwa ibe: i-molecule enkulu i-collagen kunye ne-molecule encinci ye-collagen peptides.
Iintsini ekutyeni esiqhele ukukutya zineemolekyuli ezinkulu zeprotheyini ezinobunzima bemolekyuli obungama-300,000 edaltons okanye ngaphezulu, ezingafunxwanga ngokuthe ngqo emva kokusetyenziswa, kodwa ziqhekeke zibe zii-amino acids kwinkqubo yokwetyisa, zilindele ukulungelelaniswa, kwaye oko kusenzeka. akwaziwa ukuba ngaba ekugqibeleni benza i-collagen, enezinga eliphantsi kakhulu lokufunxa.

Abantu baye balawula i-collagen kunye nobunzima be-molecular ukuya kwi-6000 daltons nge-acid-base kunye ne-enzymatic cleavage techniques kwaye bayibiza ngokuba yi-collagen peptide. I-peptide yinto ephakathi kwe-amino acids kunye neeprotheni ze-macromolecular. Ii-amino acids ezimbini okanye ngaphezulu ziphelelwe ngamanzi kwaye ziconjululwe ukuze zenze iibhondi ezininzi zepeptide ukuze zenze i-peptide, kwaye iipeptides ezininzi zigoqwe kumanqanaba amaninzi ukwenza imolekyuli yeprotheni. Iipeptides ziziqhekeza zeprotheyini ezichanekileyo ezineemolekyuli ezinobungakanani be-nanometer, ezifunxwa lula sisisu, amathumbu, imithambo yegazi kunye nolusu, kwaye izinga lokufunxa liphezulu kakhulu kunelo leeproteni ezinkulu zemolekyuli.

I-Collagen peptides ene-molecular weight of 6000 daltons okanye ngaphantsi ihlulwe kwiipeptide ezinobunzima be-molecular of 1000-6000 daltons kunye ne-peptides ene-molecular weight ye-1000 daltons okanye ngaphantsi. Ngokubanzi, inani le-amino acids kwi-oligopeptide lisuka kwisibini ukuya kwisithoba. Ngokwenani le-amino acids kwi-peptide, kukho amagama ahlukeneyo: i-compound eyenziwe yi-dehydration condensation ye-amino acid iimolekyuli ezimbini zibizwa ngokuba yi-dipeptide, kwaye ngokufana okufanayo, kukho i-tripeptide, i-tetrapeptide, i-pentapeptide, njl., kude kube yisithoba. iipeptides; ngokuqhelekileyo i-compound eyenziwe yi-dehydration condensation ye-10-50 i-amino acid molecules ibizwa ngokuba yi-polypeptide.
Kwi-1960s, kuye kwafakazelwa ukuba i-oligopeptide inokuthatyathwa ngaphandle kwesisu, enokunciphisa kakhulu umthwalo wesisu kunye nesibindi kunye nokuphucula i-bioavailability; kwaye inokuthatha inxaxheba ngokuthe ngqo kwi-synthesis ye-collagen yabantu ngaphandle kokuqhekeka kwi-amino acids, ngelixa i-peptide ayinakufezekisa ezi zinto.
Ngoko ke, kufuneka ubeke ingqalelo kwi-molecular weight of collagen peptides xa uzithenga.